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  • Title: Effects of alcohol on TMS-evoked N100 responses.
    Author: Kähkönen S, Wilenius J.
    Journal: J Neurosci Methods; 2007 Oct 15; 166(1):104-8. PubMed ID: 17727957.
    Abstract:
    TMS combined with simultaneous EEG is a novel brain imaging tool allowing investigation local excitability of human cortex. As alcohol acts through increasing function of A-type gamma-aminobutyric acid receptors and attenuating the function of glutaminergic NMDA-receptors-related excitation, we tested whether TMS-evoked N100 response which is thought to reflect cortical inhibitory processes, might be affected by alcohol. Ten healthy subjects ingested alcohol (0.8 g/kg) and EEG responses from 60 channels before and after alcohol ingestion were recorded after left motor-cortex stimulation. Alcohol almost abolished TMS-evoked N100 response. Control experiments with a piece of plastic placed between the head and coil to exclude auditory artefacts were conducted. Alcohol effects were similar when EEG responses from control experiments were subtracted from real-TMS. Alcohol-induced decrease was similar at ipsilateral, contralateral and frontal EEG sites suggesting that alcohol may change cortico-cortical connectivity of motor cortex. Alternative explanation is that alcohol has overall suppression effect on motor cortex. N100 may provide a useful marker of neural inhibition of human cortex for drug research.
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