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  • Title: Synthesis, structure and stereochemistry of quinoline alkaloids from Choisya ternata.
    Author: Boyd DR, Sharma ND, Loke PL, Malone JF, McRoberts WC, Hamilton JT.
    Journal: Org Biomol Chem; 2007 Sep 21; 5(18):2983-91. PubMed ID: 17728865.
    Abstract:
    A range of seventeen quinoline alkaloids, involving several types of oxidations during their biosynthetic pathways, have been isolated from leaves of Choisya ternata. In addition to the nine known quinoline alkaloids, eight new members of the furoquinoline family, derived mainly from prenylation at C-5 (including two novel hydroperoxides), have been identified. The absolute configurations and enantiopurity values of all chiral quinoline alkaloids have been determined. One of the isolated alkaloids, 7-isopentenyloxy-gamma-fagarine, has been used as a precursor for the chemical asymmetric synthesis of the enantiopure alkaloids: evoxine, anhydroevoxine and evodine. The possible roles of oxygenase and other oxygen-atom-transfer enzymes, in the biosynthetic pathways of the C. ternata alkaloids, have been discussed.
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