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  • Title: [C-reactive protein in the early diagnosis of postoperative infection following bone surgery].
    Author: Waleczek H, Kozianka J, Everts H.
    Journal: Chirurg; 1991 Dec; 62(12):866-70. PubMed ID: 1773631.
    Abstract:
    Of a prospective 101 patient study group after different operative osteosynthetic procedures 94 patients without postoperative infection showed a uniform acute phase response which was characterized by determination of C-reactive protein levels, ESR, WBC and body temperature. 7 patients suffering from infection in the postoperative period but no patient with non-inflammatory complications showed distinct CRP value patterns. In 4 wound infections CRP increased from day 2 to 4 and thus was the earliest sign of developing infection. Latency to the clinical diagnosis based on clinical signs, ultrasound, WBC in blood and wound drainage was up to 14 days. There was no patient with CRP increasing after day 2 but no infection. CRP is a very sensitive, non-expensive tool for early diagnosis of bacterial infection. It is superior to ESR, WBC in blood and drainage, ultrasound and diagnosis based on clinical signs.
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