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  • Title: Receptor-active growth hormone in Laron dwarfism.
    Author: Jacobs LS, Sneid DS, Garland JT, Laron Z, Daughaday WH.
    Journal: J Clin Endocrinol Metab; 1976 Feb; 42(2):403-6. PubMed ID: 177445.
    Abstract:
    The hepatic radioreceptor assay for hGH has been applied to the detection of hGH in the sera of patients with high growth hormone dwarfism (Laron dwarfism). Substantial quantities of receptor-active hGH were found in the sera of all 7 patients studied. In one patient, arginine infusion elicited a prompt increase in both immunoactive and receptor-active hGH. These observations suggest that circulating hGH in Laron dwarfism is biologically active and support the concept that the disease may be caused by a generalized defect in hGH receptors.
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