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  • Title: [Successful mitral valve replacement in osteogenesis imperfecta--a case report].
    Author: Uemura S, Harada Y, Kasegawa H, Simura H, Murakami S, Morooka N.
    Journal: Nihon Kyobu Geka Gakkai Zasshi; 1991 Nov; 39(11):2074-7. PubMed ID: 1774489.
    Abstract:
    A 34-year-old man with osteogenesis imperfecta who underwent successful mitral valve replacement due to mitral regurgitation was reported. Cardiac disease associated with osteogenesis imperfecta is very rare and only fifteen patients were operated under the extracorporeal circulation previously. While excessive hemorrhage due to tissue fragility was observed in 7 of 15 patients, perioperative course of the case reported here was completely uneventful. The difference of hemorrhagic tendency as well as etiology of osteogenesis imperfecta will be defined according to the advance of technology in collagen genetics and biochemistry in future.
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