These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ritanserin reduces abuse of alcohol, cocaine, and fentanyl in rats.
    Author: Meert TF, Awouters F, Niemegeers CJ, Schellekens KH, Janssen PA.
    Journal: Pharmacopsychiatry; 1991 Sep; 24(5):159-63. PubMed ID: 1775520.
    Abstract:
    Rats that had received 3% alcohol, 0.01% cocaine, or 0.002% fentanyl as the only beverage over 10 days showed marked preference for the drug solution when water was made available as a second fluid in a separate bottle. Treatment with low doses of ritanserin, a specific central serotonin 5-HT2 antagonist, rapidly reversed drug preference without changing total fluid intake. Quantitatively, the reduction in drug consumption was greater for alcohol than for cocaine and greater for cocaine than for fentanyl. This is probably related to differences in the reinforcing potential of the three drugs.
    [Abstract] [Full Text] [Related] [New Search]