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  • Title: Fishing for a mechanism: using zebrafish to understand spinal muscular atrophy.
    Author: Beattie CE, Carrel TL, McWhorter ML.
    Journal: J Child Neurol; 2007 Aug; 22(8):995-1003. PubMed ID: 17761655.
    Abstract:
    Motoneuron diseases cause paralysis and death due to loss of motoneurons that innervate skeletal muscle. Spinal muscular atrophy is a human motoneuron disease that is genetically linked to the survival motor neuron gene (SMN). Although SMN was identified more than a decade ago, it remains unclear how decreased levels of the SMN protein cause spinal muscular atrophy. The use of animal models, however, offers a crucial tool in determining the function of SMN in this disease. In this review, we discuss our efforts to develop a zebrafish model of spinal muscular atrophy.
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