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  • Title: Objective analysis of retinal function in HIV-positive children without retinitis using optical coherence tomography.
    Author: Moschos MM, Mostrou G, Psimenidou E, Spoulou V, Theodoridou M.
    Journal: Ocul Immunol Inflamm; 2007; 15(4):319-23. PubMed ID: 17763130.
    Abstract:
    PURPOSE: To assess the retinal nerve fiber layer thickness in children with human immunodeficiency virus disease without cytomegalovirus retinitis or visual symptoms. METHODS: Thirty-eight eyes of 19 human immunodeficiency virus-positive children (group A) with visual acuity of 20/20 or better, normal color vision testing and no ophthalmoscopically detectable disorders were prospectively examined. All subjects of group A had no history of cytomegalovirus retinitis and CD4 counts consistently above 100. Patients in group B (40 eyes of 21 patients) were human immunodeficiency virus-negative age-matched control subjects. Thickness of retinal nerve fiber layer along a 3.4-mm-diameter circle centered on the optic nerve head was evaluated using third-generation optical coherence tomography. CD8 T-lymphocyte count, presence of systemic infection, hemoglobin, hematocrit and serum beta-microglobulin levels were also recorded. RESULTS: The mean overall retinal nerve fiber layer thickness in groups A and B were 89.2 +/- 24.01 microm and 102.82 +/- 29.168 microm (SD) respectively. The difference was considered extremely significant (P < 0.0001). Group A had significantly thinner average nerve fiber layer in temporal, nasal, superior and inferior retinal areas. CONCLUSIONS: Significant retinal nerve fiber layer thinning occurs in human immunodeficiency virus-positive children with no visual impairment or ophthalmologic evidence or retinitis.
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