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  • Title: Monitoring neutrophil engraftment in allogeneic stem cell transplantation by flow cytometric analysis of neutrophil-specific antigens NA1 and NA2.
    Author: Inukai T, Uno K, Taniguchi K, Goi K, Tezuka T, Nemoto A, Takahashi K, Sato H, Akahane K, Hirose K, Honna H, Kagami K, Hiraoka A, Tanihiro M, Nakazawa S, Sugita K.
    Journal: Br J Haematol; 2007 Oct; 139(2):280-3. PubMed ID: 17764467.
    Abstract:
    Neutrophil-specific antigen (NA) expression on neutrophils was analysed in 18 Japanese children before and after allogeneic stem cell transplantation (allo-SCT) with myeloablative regimen. Donor-recipient NA-incompatibility was present in one of eight NA1/NA2 heterozygous patients and eight of 10 NA1/NA1 or NA2/NA2 homozygous patients. After allo-SCTs from NA-incompatible donors, a neutrophil recipient-to-donor conversion was confirmed in all cases. Conversion to donor NA type was complete before the absolute neutrophil count reached 0.1 x 10(9)/l. These observations indicate that flow cytometric analysis of NA antigens is a simple and useful method for monitoring neutrophil engraftment in NA-incompatible allo-SCT.
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