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  • Title: [Aging effects on the light response of the interphotoreceptor matrix as revealed by binding of Ricinus communis agglutinin-1].
    Author: Uehara F, Ohba N, Yasumura D, LaVail MM.
    Journal: Nippon Ganka Gakkai Zasshi; 1991 Dec; 95(12):1244-7. PubMed ID: 1776604.
    Abstract:
    This study intended to explore whether the light response of the interphotoreceptor matrix (IPM) is affected by aging. The binding pattern of fluorescence-labeled Ricinus communis agglutinin-1 (RCA) to IPM was examined histochemically in 2 month-old and 1.5 year-old rats under light- and dark-adapted conditions. Two month-old animals showed obvious light-evoked changes in the rod associated IPM: the photoreceptor inner segment zone showed a greater fluorescence than the outer segment zone in the light, whereas the staining-intensity of the former was less than that of the latter in the dark. On the other hand, 1.5 year-old rats did not show such light-evoked IPM responses as in 2 month-old animals: no light-dark differences were found in RCA-1 binding. The scarce, linear, preferential binding of RCA-1 to the cone-associated IPM was the same in both lighting conditions independent of the age.
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