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  • Title: Serum cytokines profiles in Iranian patients with preeclampsia.
    Author: Mansouri R, Akbari F, Vodjgani M, Mahboudi F, Kalantar F, Mirahmadian M.
    Journal: Iran J Immunol; 2007 Sep; 4(3):179-85. PubMed ID: 17767018.
    Abstract:
    BACKGROUND: Preeclampsia is a major cause of mortality and morbidity and is also a leading cause of preterm birth and intrauterine growth retardation. Several studies have reported abnormal levels of cytokines in women with preeclampsia. OBJECTIVES: To detect serum levels of various cytokines in pregnant women with and without preeclampsia in the third trimester of pregnancy. METHODS: Thirty patients with preeclampsia and thirty normal pregnant women were enrolled in the study. Blood samples were taken and serum levels of IFN gamma, IL-12p70, IL-18, IL-15, IL-4 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Preeclamptic women had significantly increased levels of circulating IL-12p70 (p < 0.05), IL-18 (p < 0.001), IL-4 (p < 0.001), IL-15 (p < 0.05) and IFN gamma (p < 0.001). By contrast, circulating levels of IL-10 were not significantly different between the two groups. CONCLUSIONS: The present study supports the hypothesis of altered immune response in preeclampsia and suggests that dysregulation of cytokine expression occurs in preeclampsia with increased levels of IFN gamma, IL-12p70, IL-15, IL-18 and IL-4.
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