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  • Title: [The associations of serum gastrin level with Helicobacter pylori infection].
    Author: Nie XR, Zhou T, Pan KF, Li WQ, Feng GS, Zhang Y, Zhang L, You WC.
    Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 2007 Jun; 41 Suppl():87-9. PubMed ID: 17767867.
    Abstract:
    OBJECTIVE: To investigate the associations of serum gastrin-17 (G-17) concentration with helicobacter pylori (Hp) infection. METHODS: A (13)C-urea breath and ELISA test to determine the Helicobacter pylori status and to detect the serum gastrin concentration was conducted in 242 villagers in Linqu of Shandong Province, a high gastric cancer prevalence area in China. RESULTS: Of 242 subjects, 65 of 111 were found Hp-positive in males (58.56%), compared with 65 of 131 in females (49.62%) (chi(2) = 1.932, P = 0.165). The statistical difference was not observed among different age groups (chi(2) = 4.185, P = 0.123). The average level of G-17 among 242 subjects was (24.43 +/- 25.46) pmol/L and it was statistically higher in females (29.87 +/- 28.18) pmol/L than that in males (18.01 +/- 20.11) pmol/L (Z = -3.618, P < 0.001). However, there was no statistical difference found among age groups (chi(2) = 1.948, P = 0.378). The G-17 level in Hp-negative group (35.50 +/- 30.92) pmol/L was observed significantly higher than in Hp-positive group (14.90 +/- 13.79) pmol/L (Z = 5.368, P = 0.0001). CONCLUSION: The G-17 concentration was found higher in Hp-negative subjects than in Hp-positive subjects, and higher in female than in male, but no difference was found among age groups.
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