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  • Title: The osteoclast-not always guilty.
    Author: Mundy GR, Edwards JR.
    Journal: Cell Metab; 2007 Sep; 6(3):157-9. PubMed ID: 17767902.
    Abstract:
    Osteopetrosis is usually regarded as the disease of nonfunctioning osteoclasts, with a consequent accumulation of osseocartilaginous material in the bone marrow. A recent report shows that, in some patients with the rare autosomal recessive form of the disease, the osteoclast defect may be non-cell autonomous, in this case due to a mutation in RANKL, the protein that normally controls osteoclast formation and activity.
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