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  • Title: Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative.
    Author: Bitsch R, Wolf M, Möller J, Heuzeroth L, Grüneklee D.
    Journal: Ann Nutr Metab; 1991; 35(5):292-6. PubMed ID: 1776825.
    Abstract:
    The bioequivalence of thiamin in 2 therapeutically used preparations was tested in 10 healthy young men. Thiamin was orally administered either as lipophilic benfotiamine or as water-soluble thiamin mononitrate. Biokinetic data, measured as area under the curve and maximal concentration in plasma and hemolysate after ingestion, demonstrated a significantly improved bioavailability from the lipophilic derivative despite an ingested dose of only 40% as compared with the water-soluble salt. A superior cellular efficacy of benfotiamine was also concluded from the short-term stimulation of the thiamin-dependent transketolase activity in erythrocytes.
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