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  • Title: Increased expression of the proto-oncogene, c-myc, in human neuroblastoma cells by reversible inhibition of cell growth.
    Author: Fukuchi K, Tomoyasu S, Watanabe K, Suzuki H, Kaetsu T, Takagi Y, Tsuruoka N, Gomi K.
    Journal: Anticancer Res; 1991; 11(6):1967-73. PubMed ID: 1776829.
    Abstract:
    Expression of the proto-oncogenes N-myc and c-myc in the human neuroblastoma cell line, IMR32, was examined after reversible inhibition of DNA synthesis by treatment with deferoxamine. After 48 h treatment with 10(-5) M deferoxamine, the number of c-myc expressing cells doubled, while N-myc expressing cells did not change. The expression level of c-myc in each cell also increased. These results suggested that the synthesis of cellular factor(s) involved in the degradation of c-myc RNA or its product was suppressed by reversible inhibition of cell growth. The regulatory mechanisms of expression of N-myc and c-myc may be distinct.
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