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Title: Amplification of the epidermal growth factor receptor gene in human gliomas. Author: Torp SH, Helseth E, Ryan L, Stølan S, Dalen A, Unsgaard G. Journal: Anticancer Res; 1991; 11(6):2095-8. PubMed ID: 1776845. Abstract: Biopsy specimens of 19 human gliomas (10 glioblastomas, 2 anaplastic astrocytomas, 4 astrocytomas, one mixed glioma, one oligodendroglioma and one ependymoma) were examined for amplification of tumour-related genes located on chromosome 7: the proto-oncogene c-erb-B1 (encoding the epidermal growth factor receptor (EGFR], the proto-oncogene c-met, the platelet-derived growth factor A-chain gene, and the plasminogen activator inhibitor type-1 gene. Gene amplification was observed in 6 glioblastomas, and the EGFR gene was the only chromosome-7-gene examined that was amplified. The selective EGFR gene amplification in human glioblastomas suggests its potential role in the progression of some of these tumours.[Abstract] [Full Text] [Related] [New Search]