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  • Title: [Effects of growth factors on growth of stromal CFU-f in mouse bone marrow cell cultures].
    Author: Gorskaia IuF, Fridenshteĭn AIa, Golovanova TA.
    Journal: Biull Eksp Biol Med; 1991 Dec; 112(12):615-7. PubMed ID: 1777628.
    Abstract:
    Purified mouse IL-1 at doses 15-100 mu/ml inhibits the growth of stromal clonogenic cells /CFU-f/ both in full bone marrow cell cultures /F-cultures/ and in adherent bone marrow cell cultures /A-cultures/. Rec. human TNF-alpha inhibits growth of these cells at doses greater than 50 u/ml, but stimulates it /in 1.5 fold increase/at low doses /0.1-20 u/ml/ in cultures of both types. Rec. mouse IL-3 at doses 0.8-50 mu/ml slightly increases/in 1.6 fold increase/the in vitro growth of CFU-f and inhibits it at low doses in F-cultures. In A-cultures this factor stimulates CFU-f growth at all doses tested, but this stimulating effect takes place if only explantation density of mouse bone marrow cells in sufficiently high.
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