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  • Title: High-performance liquid chromatography of urinary oligosaccharides in the diagnosis of glycoprotein degradation disorders.
    Author: Hommes FA, Varghese M.
    Journal: Clin Chim Acta; 1991 Dec 16; 203(2-3):211-24. PubMed ID: 1777982.
    Abstract:
    Urinary oligosaccharides can be separated by high-performance anion-exchange chromatography using a Dionex CarboPac PA1 column, elution with aqueous sodium hydroxide and sodium acetate solutions and detection by pulsed amperometry. Each of the urines of patients with glycoprotein degradation disorders yielded a pattern of oligosaccharide excretion unique for that disorder, facilitating an unambiguous diagnosis. The method is sensitive (10 microliters of urine required) and fast (40 min).
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