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  • Title: Assessment of cold induced alterations in catecholamine turnover of lean and glutamate-treated obese rats.
    Author: Arndt T, Rehorek A, Müller F.
    Journal: Exp Clin Endocrinol; 1991; 98(3):207-11. PubMed ID: 1778240.
    Abstract:
    Excretion of norepinephrine (NE) and vanillylmandelic acid (VMA) in urine as well as NE-turnover in tissues from lean and glutamate-treated obese rats were determined in warm and cold environment. NE-and VMA-excretion in urine was elevated by cold exposure, indicating an activation of the sympathetic nervous system in animals of both groups. Organspecific NE-turnover responds with higher sensitivity to cold in obese rats but without complete compensation in brown adipose tissue. Urinary NE- and VMA- excretion as well as NE-turnover in organs confirmed that cold exposure activates the sympathetic nervous system. Measurement of NE-turnover in tissues gives organspecific information regarding alterations in sympathetic activity during cold exposure, whereas excretion of NE and VMA in urine is a summarizing measure for the whole body turnover only.
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