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  • Title: Regulation of epidermal growth factor receptors in rat gastric mucosa: effect of gastric ulceration.
    Author: Nomura H, Iwakawa S, Saito Y, Hori R, Okumura K.
    Journal: J Pharmacobiodyn; 1991 Sep; 14(9):527-31. PubMed ID: 1779407.
    Abstract:
    The effect of experimental ulcers on the binding of human epidermal growth factor (hEGF), beta-urogastrone, to plasma membranes isolated from rat gastric mucosa was studied in order to develop hEGF as an anti-ulcer drug. The binding of [125I]hEGF to the gastric plasma membranes was significantly decreased 1 h after treatment with aspirin (300 mg/kg) and after 12 h of water-immersion stress. However, the number of EGF binding sites was increased 12 h after aspirin administration. There was little change in the binding of [125I]insulin to the gastric plasma membranes in response to water-immersion stress. These results indicate that changes in EGF binding to its receptors occur on plasma membranes of the rat gastric mucosa during ulcer.
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