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  • Title: Template-directed extension of a guanosine 5'-phosphate covalently attached to an oligodeoxycytidylate template.
    Author: Rodriguez L, Orgel LE.
    Journal: J Mol Evol; 1991 Dec; 33(6):477-82. PubMed ID: 1779431.
    Abstract:
    We have prepared molecules in which a guanosine 5'-phosphate (pG) residue is attached to the 3' terminus of a decadeoxycytidylate (pdC)10 template via diamine linkers H2N(CH2)nNH2, n = 4-7. The pG residue acts as a primer and is extended very efficiently by incubation with activated pG derivatives to give products containing 6-9 G residues in greater than 80% yield. The detailed nature of the product distribution is discussed.
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