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  • Title: A differentiation stimulating factor induces cell sensitivity to 3':5'-cyclic AMP pulses in dictyostelium discoideum.
    Author: Klein C, Darmon M.
    Journal: Proc Natl Acad Sci U S A; 1976 Apr; 73(4):1250-4. PubMed ID: 177982.
    Abstract:
    During the first few hours of starvation, Dictyostelium discoideum amoebae excrete a macromolecule, probably a glycoprotein, which stimulates cell differentiation to aggregation competence. 3':5'-Cyclic AMP pulses, which mimic the chemotactic signal, and this factor (differentiation stimulating factor) are shown to exert a cooperative effect in inducing cell differentiation. Data suggest that the appearance of the factor determines the moment amoebae become responsive to cyclic AMP pulses.
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