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  • Title: [Evaluation of the effectiveness of monotherapy in the treatment of epilepsy].
    Author: Brignolio F, Verzè L, Baruchello M.
    Journal: Minerva Med; 1991 Dec; 82(12):859-62. PubMed ID: 1780094.
    Abstract:
    On 44 patients undergoing monotherapy, with total plasma levels of drug therapeutic range, 33 had a reduction of the frequency of seizures, while the remaining 11 were unmodified. There was 90% improvement in Primary Generalized seizures, 73% in Secondary Generalized and 62% in Partial Complex; 27% of PC, 16% of PG and 16% of SG shifted to polytherapy. Considering that monotherapy can be better managed and is less toxic, we can recommend it as first choice treatment in newcomers, as a maintenance therapy, and as treatment of choice for the gradual elimination of therapy.
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