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  • Title: Penicidones A-C, three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp.
    Author: Ge HM, Shen Y, Zhu CH, Tan SH, Ding H, Song YC, Tan RX.
    Journal: Phytochemistry; 2008 Jan; 69(2):571-6. PubMed ID: 17804027.
    Abstract:
    Along with the known secondary metabolites lumichrome, physcion, and emodin-1,6-dimethyl ether, three alkaloids named penicidones A-C (1-3) were isolated from the culture of Penicillium sp. IFB-E022, an endophytic fungal strain residing in the stem of Quercus variabilis (Fagaceae). The structures of penicidones A-C were established by a correlative interpretation of spectroscopic data including IR, UV and HR-ESI-MS, as well as by analysis of a set of 1D and 2D NMR experiments. The stereochemistry of compounds 1 and 2 was obtained by comparison of the optical rotation with those of vermistatin and its analogues. Penicidones A-C were the first group of natural products possessing a penicidone framework. Compounds 1-3 exhibited moderate cytotoxicity against four cancer cell lines.
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