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  • Title: Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists.
    Author: Krushinski JH, Schaus JM, Thompson DC, Calligaro DO, Nelson DL, Luecke SH, Wainscott DB, Wong DT.
    Journal: Bioorg Med Chem Lett; 2007 Oct 15; 17(20):5600-4. PubMed ID: 17804228.
    Abstract:
    Analogues of pindolol, 1-(1H-indol-4-yloxy)-3-isopropylamino-propan-2-ol, were synthesized and evaluated as 5-HT(1A) receptor antagonists. The structural features required for optimal binding to the 5-HT1A receptor are as follows: S-2-propanol linker, 4-indoloxy substituent, and a large lipophilic cyclic amine substituent.
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