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Title: Glomerulopressin activity in carbon tetrachloride-induced cirrhosis in male rats. Author: Elias AN, Khamiseh G, Vaziri ND. Journal: Ren Fail; 1991; 13(4):253-7. PubMed ID: 1780493. Abstract: The activity of glomerulopressin, a putative renal vasoregulatory hormone that is synthesized in the liver, was assayed in male rats with carbon tetrachloride-induced cirrhosis and the results were compared to glomerulopressin activity in normal-control and pair-fed animals. Glomerulopressin activity in blood samples collected from the hepatic vein of the cirrhotic group was significantly lower than the activity in the normal-control and pair-fed groups. Glomerulopressin activity in the normal-control and the pair-fed groups were not significantly different. The data support the concept that glomerulopressin deficiency in liver disease, such as cirrhosis, may play a role in the genesis of the functional renal failure associated with liver disease.[Abstract] [Full Text] [Related] [New Search]