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  • Title: [Intervals between hospitalisations in schizophrenia patients under antipsychotics in depot-form versus oral second generation antipsychotics].
    Author: Gutwinski S, Müller P, Koller M.
    Journal: Psychiatr Prax; 2007 Sep; 34(6):289-91. PubMed ID: 17806015.
    Abstract:
    OBJECTIVE: The reduction of the frequency of rehospitalisation is important for improving the outcomes for patients with schizophrenia. METHODS: This study compares the rate of rehospitalisation between patients with antipsychotics in depot-form (n = 77) and oral second-generation antipsychotics (SGA) (n = 156). RESULTS: Patients with antipsychotics in depot-form had lower risk of rehospitalisation than with SGAs in oral-form after 24 months (p = 0.027) and 36 months (p = 0.018) (Kaplan-Meyer survival analysis, Log-Rank). Long intervals between two hospitalisations were found for flupentixol depot and clozapine. CONCLUSIONS: Antipsychotics in depot-form require and active and close outpatient treatment, which may account for long intervals between hospitalisation improved outcomes for patients with schizophrenia.
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