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  • Title: The occurrence in a neonate of a pancreatic adenoma with nesidioblastosis in the tumor.
    Author: Dahms BB, Lippe BM, Dakake C, Fonkalsrud EW, Mirra JM.
    Journal: Am J Clin Pathol; 1976 Apr; 65(4):462-6. PubMed ID: 178172.
    Abstract:
    A newborn with persistent hypoglycemia and fixed insulin secretion unresponsive to medical management underwent 80% pancreatectomy. A 1-cm. nonencapsulated islet-cell adenoma near the tail of the pancreas was identified histologically. Islet-cell granules stained with indirect aldehyde fuchsin. Throughout the tumor, areas of nesidioblastosis were identified. The persistence of this embryologic process suggests a basic mechanism for the adenoma formation.
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