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  • Title: Growth pattern switch of renal cells and expression of cell cycle related proteins at the early stage of diabetic nephropathy.
    Author: Zhang Y, Shi Y, Liu Y, Dong H, Liu M, Li Y, Duan H.
    Journal: Biochem Biophys Res Commun; 2007 Nov 09; 363(1):159-64. PubMed ID: 17825795.
    Abstract:
    Renal hypertrophy, partly due to cell proliferation and hypertrophy, has been found correlated to renal function deterioration in diabetes mellitus. We screened the up-regulated cell cycle related genes to investigate cell growth and the expression of cell cycle regulating proteins at the early stage of diabetic nephropathy using STZ-induced diabetic rats. Cyclin E, CDK(2) and P(27) were found significantly up-regulated in diabetic kidney. Increased cell proliferation in the kidney was seen at day 3, peaked at day 5, and returned to normal level at day 30. Cyclin E and CDK(2) expression also peeked at day 5 and P(27) activity peaked at day 14. These findings indicate that a hyperplastic growth period of renal cells is followed by a hypertrophic growth period at the early stage of diabetes. The growth pattern switch may be regulated by cell cycle regulating proteins, Cyclin E, CDK(2), and P(27).
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