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  • Title: Long-term evaluation of Sinemet CR in parkinsonian patients with motor fluctuations.
    Author: Hutton JT, Morris JL.
    Journal: Can J Neurol Sci; 1991 Nov; 18(4):467-71. PubMed ID: 1782612.
    Abstract:
    The safety and efficacy of Sinemet CR, a controlled-release formulation of carbidopa/levodopa, were investigated in a three year, open-label trial involving 18 parkinsonian patients with fluctuating motor response. The average daily levodopa dosing frequency did not change significantly during long-term treatment. Efficacy measures generally revealed a gradual progression of parkinsonian disability. Patient diaries of motor fluctuations revealed relative stability of time "on" but with a tendency toward increased time "on with dyskinesias" over the 36 month follow-up period. There were no adverse laboratory results deemed to be related to Sinemet CR and no unexpected side effects were observed.
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