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  • Title: Juvenile hormone activity of ethyl 4-(2-aryloxyhexyloxy)benzoates with precocious metamorphosis-inducing activity.
    Author: Fujita N, Ashibe K, Yamada N, Shiotsuki T, Kiuchi M, Kuwano E.
    Journal: Biosci Biotechnol Biochem; 2007 Sep; 71(9):2333-4. PubMed ID: 17827698.
    Abstract:
    Ethyl 4-[2-(6-methyl-3-pyridyloxy)hexyloxy]benzoate (1) and ethyl 4-(2-phenoxyhexyloxy)benzoate (2), which induce precocious metamorphosis in larvae of Bombyx mori, a clear sign of juvenile hormone (JH) deficiency, showed JH activity when topically applied to allatectomized 4th instar larvae of B. mori. Compounds 1 and 2 induced precocious metamorphosis with doses at which they were effective as JH agonists.
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