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  • Title: Human adenohypophysis in Nelson syndrome. Ultrastructural and clinical study.
    Author: Garcia JH, Kalimo H, Givens JR.
    Journal: Arch Pathol Lab Med; 1976 May; 100(5):253-8. PubMed ID: 178289.
    Abstract:
    The manifestations that comprise the disease known as Nelson syndrome are pituitary hyperplasia and cutaneous hyperpigmentation, which sometimes follow bilateral adrenalectomy, in patients with hypercortisolism. We present a comprehensive endocrinologic, structural study of a patient in whom the evidence obtained supports the hypotheses that: (a) the primary disorder in this form of hypercortisolism is probably hypothalamic; (b) the hyperplasia of the adenohypophysis, following adrenalectomy, is closely associated with lowered plasma cortisol levels; and (c) the cillular hyperplasia in the adenohypophysis involves primarily the corticotroph, a cell believed to be associated with the secretion of adrenocorticotrophic hormone and melanocyte-stimulating hormone.
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