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  • Title: [Effects of EGF and retinoic acid on differentiation of squamous cell carcinoma cells].
    Author: Harada H, Tashiro H, Kukita T, Kurisu K.
    Journal: Fukuoka Igaku Zasshi; 1991 Dec; 82(12):655-8. PubMed ID: 1783357.
    Abstract:
    Using monoclonal antibody, G6K12, a novel differentiation marker of keratinocyte, we examined the effect of EGF and retinoic acid on the differentiation of SCC-25, a cell line established from human squamous cell carcinoma. EGF inhibited the expression of cell-surface differentiation marker in low cell-density, but not in high cell-density. Retinoic acid (more than 10(-8) M) inhibited the expression of the antigens. The terminal differentiation of SCC-25 cells occurred at the condition of high cell density. These results obtained demonstrate that EGF and retinoic acid inhibit the terminal differentiation of SCC-25 cells, and that the cell density is the important factor for the commitment of the terminal differentiation.
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