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  • Title: The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres.
    Author: Vandelli MA, Forni F, Iannuccelli V, Cameroni R.
    Journal: J Pharm Belg; 1991; 46(6):381-8. PubMed ID: 1783972.
    Abstract:
    The effect of the concentration of a cross-linking agent (gelatin hardener) on gelatin microspheres was evaluated. A concentration increase of the gelatin hardener (formaldehyde) produced a decrease of drug loading, swelling degree and drug release rate. The cross-linking agent concentration affected also the kinetics of water absorption and drug release. This paper suggests a decreasing significance of the diffusion-type mechanism of drug release as the concentration of the cross-linking agent increased.
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