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  • Title: Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model.
    Author: Thomas GP, Varma RK.
    Journal: Methods Find Exp Clin Pharmacol; 1991 Sep; 13(7):459-62. PubMed ID: 1784143.
    Abstract:
    Ouabain (1.0 x 10(-6) M) produced a uniform, consistent and reproducible arrhythmia on paced guinea pig left atrium bathed in Ringer-Locke solution. A second spell of arrhythmia of similar intensity and pattern, which had the same latency to onset, was reproduced 60 min after the first spell of arrhythmia. Lignocaine (3.46 x 10(-5) M) and propranolol (1.69 x 10(-5) M) gave full protection against the second spell of arrhythmia, whereas lower doses of these drugs were able to delay the onset and reduce the duration. Clonidine (3.75 x 10(-5) M), however, was found to be ineffective. This model can be used for the detection and assessment of directly acting antiarrhythmics in very low concentrations, since this is a sensitive and reliable method.
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