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  • Title: Coverage and error models of protein-protein interaction data by directed graph analysis.
    Author: Chiang T, Scholtens D, Sarkar D, Gentleman R, Huber W.
    Journal: Genome Biol; 2007; 8(9):R186. PubMed ID: 17845715.
    Abstract:
    Using a directed graph model for bait to prey systems and a multinomial error model, we assessed the error statistics in all published large-scale datasets for Saccharomyces cerevisiae and characterized them by three traits: the set of tested interactions, artifacts that lead to false-positive or false-negative observations, and estimates of the stochastic error rates that affect the data. These traits provide a prerequisite for the estimation of the protein interactome and its modules.
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