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  • Title: Cassane furanoditerpenoids from the seed kernels of Caesalpinia bonduc from Thailand.
    Author: Pudhom K, Sommit D, Suwankitti N, Petsom A.
    Journal: J Nat Prod; 2007 Sep; 70(9):1542-4. PubMed ID: 17848088.
    Abstract:
    Three new cassane furanoditerpenoids ( 1- 3), together with 13 known cassane diterpenes ( 4- 16), were isolated from the EtOAc extract of the seed kernels of Caesalpinia bonduc. Their structures were elucidated on the basis of spectroscopic analysis, mainly NMR and MS. Compounds 1- 3 exhibited good antimalarial activity against the multidrug-resistant K1 strain of Plasmodium falciparum, while compound 4 was inactive. None of the compounds were cytotoxic against any of the tumor cell lines tested.
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