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  • Title: Perfluorochemical emulsion effect on human albumin binding of valproic acid.
    Author: Parsons DL, Ravis WR, Huang HC.
    Journal: Res Commun Chem Pathol Pharmacol; 1991 Aug; 73(2):245-8. PubMed ID: 1784838.
    Abstract:
    At 37 degrees C, valproic acid was weakly bound by a PFCE through an interaction with the emulsifiers that was independent of both buffer and PFCE concentration. The binding by PFCE was dependent on valproic acid concentration in 0.1 M buffer, but not in 0.2 M buffer. The addition of PFCE to 4% HSA increased the percent free valproic acid due to both HSA dilution and displacement of HSA bound drug. This displacement was apparently due to an interaction with the PFC liquids and/or intact PFCE droplets, and with the oleic acid component of the PFCE.
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