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  • Title: Comparison of the effectiveness of dithiocarbamates on the excretion and distribution of cadmium in mice.
    Author: Shimada H, Funakoshi T, Kiyozumi M, Kojima S.
    Journal: Res Commun Chem Pathol Pharmacol; 1991 Aug; 73(2):249-52. PubMed ID: 1784839.
    Abstract:
    Sodium N-benzyl-D-glucamine dithiocarbamate (BGD), sodium N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD), and sodium N-p-methoxybenzyl-D-glucamine dithiocarbamate (MeOBGD) were evaluated for their efficacy in the distribution and excretion of cadmium in mice exposed to cadmium. Mice were injected i.p. with 109CdCl2 (1 mg Cd/kg and 74 kBq of 109Cd/mouse) and 30 min or 24 h later, they were injected i.p. with chelating agents (5% of an LD50). The results of this study indicated that the injection of HBGD to mice pretreated with cadmium can remove cadmium from the body without redistribution of cadmium to the brain, testes, and heart more effectively than that of BGD or MeOBGD.
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