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  • Title: An Efficient one-pot Biginelli condensation of aliphatic aldehydes catalyzed by zinc bromide under solvent-free conditions.
    Author: Yu Y, Liu D, Liu C, Jiang H, Luo G.
    Journal: Prep Biochem Biotechnol; 2007; 37(4):381-7. PubMed ID: 17849292.
    Abstract:
    Zinc bromide catalyzes the three component condensation reaction of an aldehyde, urea, and beta-ketoester or beta-diketone under solvent-free conditions to afford the corresponding dihydropyrimidinones (DHPMs) with moderate to high yields in short reaction time. The present method is very effective for the Biginelli condensation of aliphatic aldehydes.
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