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  • Title: [Effects of chronic Semax administration on exploratory activity and emotional reaction in white rats].
    Author: Vilenskiĭ DA, Levitskaia NG, Andreeva LA, Alfeeva LIu, Kamenskiĭ AA, Miasoedov NF.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2007 Jun; 93(6):661-9. PubMed ID: 17850024.
    Abstract:
    Effects of chronic intranasal administration of ACTH(4-10) analog Semax (MEHFPGP) on exploratory activity, anxiety level, and depression-like behaviour were studied in white rats. The peptide was injected daily in dose 0.05 mg/kg during 10 or 14 days. It was shown that chronic Semax administration at 1-2 weeks induced anxiolytic and antidepressant effects but did not influenced the exploratory activity in non-stressogenic environment. The Semax effects may be the results of activation of the brain serotoninergic system as well as increased BDNF expression in the rat hippocampus.
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