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  • Title: [Study on the efficacy of hepatitis B virus vaccination and its influencing factors among children in rural area of Jiangsu province].
    Author: Zhai XJ, Wang H, Zhu FC, Yu JX, Chen YZ, Qiu XP, Gu SK, Liu SL, Qin LM, Liang ZL, Zhuang H.
    Journal: Zhonghua Liu Xing Bing Xue Za Zhi; 2007 Apr; 28(4):322-5. PubMed ID: 17850694.
    Abstract:
    OBJECTIVE: To evaluate the efficacy of hepatitis B viruse (HBV) vaccination and its influencing factors among children in rural area of Jiangsu province. METHODS: Twenty-five hundred and twenty-two children born after 1998 in rural area were selected as the study population using multistage cluster sampling method. HBsAg and anti-HBs were detected by enzyme linked immunoassay (ELISA) and radio-immunoassay (RIA), respectively. Anti-HBs negative children were boosted using different hepatitis B vaccines and the efficacy was compared. Factors causing HBV infection in HBsAg positive children were also investigated. RESULTS: HBsAg positive rates in 1-7 year olds were 0.28%-1.28%, and the anti-HBs positive rates decreased from 76.7% to 45.5%. The HBsAg positive rate in children not timely vaccinated was significantly higher than those with HBV vaccine injection within 24 hours after birth (1.4% vs. 0.5%, P = 0.031). More than 90% of the anti-HBs negative children had protective level of anti-HBs after boosted with HBV vaccine. CONCLUSION: HBsAg positive rate in children born after 1998 in rural area of Jiangsu province decreased significantly, with an average of 0.8%. The reason for HBsAg carriage in children might be attributed to mother-to-infant transmission or not timely HBV vaccination.
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