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  • Title: Synthesis of chalcone derivatives on steroidal framework and their anticancer activities.
    Author: Saxena HO, Faridi U, Kumar JK, Luqman S, Darokar MP, Shanker K, Chanotiya CS, Gupta MM, Negi AS.
    Journal: Steroids; 2007 Nov; 72(13):892-900. PubMed ID: 17850837.
    Abstract:
    Chalcone derivatives on estradiol framework have been synthesized. Some of the derivatives showed potent anticancer activity against some human cancer cell lines. Compounds 9 and 19 showed potent activity against MCF-7, a hormone dependent breast cancer cell line. Chalcone 7 was further modified to the corresponding indanone derivative (19) using the Nazarov reaction, which showed better activity than the parent compound against the MCF-7 breast cancer cell line. Active anticancer derivatives were also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that chalcone derivatives showing cytotoxicity against cancer cell lines did not affect the fragility of erythrocytes and hence may be considered as non-toxic to normal cells.
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