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  • Title: Young-onset sporadic amyotrophic lateral sclerosis: a distinct nosological entity?
    Author: Gouveia LO, de Carvalho M.
    Journal: Amyotroph Lateral Scler; 2007 Dec; 8(6):323-7. PubMed ID: 17852021.
    Abstract:
    There are few reports describing young-onset amyotrophic lateral sclerosis (ALS). Age at onset is a prognostic factor in ALS, and thus it is relevant to investigate the clinical features of very young ALS patients. We describe three young-onset ALS cases and review the literature. SOD1 mutations were not identified. Our cases and 24 others from the literature indicate that young-onset ALS is characterized by slowly progressive symmetrical weakness; nevertheless, progression is variable. Young-onset ALS seems to be a distinct clinical syndrome but its aetiological background is largely unknown.
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