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  • Title: Bulk modification of PDMS microchips by an amphiphilic copolymer.
    Author: Xiao Y, Yu XD, Xu JJ, Chen HY.
    Journal: Electrophoresis; 2007 Sep; 28(18):3302-7. PubMed ID: 17854125.
    Abstract:
    A simple and rapid bulk-modification method based on adding an amphiphilic copolymer during the fabrication process was employed to modify PDMS microchips. Poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) was used as the additive substance. Compared to the native PDMS microchips, both the contact angle and the EOF of the bulk-modified PDMS microchips decreased. The effects of the additive loading and the pH on the EOF were investigated in detail. The bulk-modified PDMS microchips exhibited reproducible and stable EOF behavior. The application of the bulk-modified PDMS microchips was also studied and the results indicated that they could be successfully used to separate amino acids and to suppress protein adsorption.
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