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  • Title: [The activity of etoposide (VP16) in combination chemotherapy against human bladder cancer cells in vitro].
    Author: Hattori T, Satoh M, Terashima Y, Nishimura T, Akimoto M.
    Journal: Hinyokika Kiyo; 1991 Sep; 37(9):995-8. PubMed ID: 1785427.
    Abstract:
    The activity of Etoposide (VP16) in combination chemotherapy against four human transitional cell carcinoma cell lines of bladder (TCCaB) was determined by in vitro colony formation assay. Four anti-tumor agents (methotrexate: MTX, vinblastine: VBL, adriamycin: ADM, cisplatin: DDP) were used for combination chemotherapy with VP16. The ADM + VP16 combination exhibited a strong synergistic antitumor effect against the human TCCaBs compared with other combinations in this study. The combination chemotherapy of ADM + VP16 may be useful as a new chemotherapeutic regimen for advanced bladder cancer.
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