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  • Title: [Effect of isoflavones in regulating the transcription of target genes through estrogen receptors].
    Author: Meng QS, Zhu XY, Tang XL, Ma B, Ni X.
    Journal: Zhong Xi Yi Jie He Xue Bao; 2007 Sep; 5(5):577-80. PubMed ID: 17854564.
    Abstract:
    OBJECTIVE: To observe the transcriptional regulation of the two isoflavones genistein and daidzein on target genes. METHODS: In this study, we used ERalpha or ERbeta over-expressing Hela cells to observe the transcriptional regulation of genistein and daidzein on ERE reporter gene with calcium-phosphate method, and furthermore observing the effects of phytoestrogen antagonist ICI 182780 on their activation. RESULTS: Our results showed that both genistein and daidzein could activate ERE receptor gene through ERalpha and ERbeta, and these effects could be blocked by ICI 182780. CONCLUSION: Both genistein and daidzein can mimic estrogen's effect to activate the transcription of target genes through binding to the ERs.
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