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  • Title: Divergent synthesis of cytotoxic styryl lactones from D-xylose. The first total synthesis of (+)-crassalactone C.
    Author: Popsavin V, Benedeković G, Srećo B, Popsavin M, Francuz J, Kojić V, Bogdanović G.
    Journal: Org Lett; 2007 Oct 11; 9(21):4235-8. PubMed ID: 17867695.
    Abstract:
    A new divergent approach to (+)-goniofufurone (1) and 7-epi-(+)-goniofufurone (2), as well as the first total synthesis of crassalactone C (3), has been achieved starting from D-xylose. In a preliminary bioassay, all three natural products 1, 2, and 3 showed remarkable in vitro antiproliferative activities against K562, Raji, and HeLa neoplastic cell lines.
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