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  • Title: Synthesis and antibacterial activity of pyranmycin derivatives with N-1 and O-6 modifications.
    Author: Li J, Chiang FI, Chen HN, Chang CW.
    Journal: Bioorg Med Chem; 2007 Dec 15; 15(24):7711-9. PubMed ID: 17870543.
    Abstract:
    Continuing from our ongoing effort in modifying aminoglycoside antibiotics with the goal of counteracting drug resistant bacteria, we have further derivatized pyranmycin, a neomycin class aminoglycoside antibiotic, with modifications at O-6 and N-1 positions. The revealed SAR results demonstrated that the antibacterial activity of pyranmycin can be modulated by different acylic substituents at O-6. Among these results, the 6-O-aminoethyl derivative, JT050, showed effective activity against resistant strain Escherichia coli (pTZ19U-3) and E. coli (pSF815), which provides insight into further structural modifications.
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