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  • Title: Subclinical neurological abnormalities in children with celiac disease receiving a gluten-free diet.
    Author: Cakir D, Tosun A, Polat M, Celebisoy N, Gokben S, Aydogdu S, Yagci RV, Tekgul H.
    Journal: J Pediatr Gastroenterol Nutr; 2007 Sep; 45(3):366-9. PubMed ID: 17873753.
    Abstract:
    OBJECTIVES: Because clinically evident manifestations are frequent in adults with celiac disease (CD), we aimed to investigate whether early neurological abnormalities may be detected in children with CD. METHODS: Electroencephalography, electromyography, and somatosensory evoked potentials were performed in children with CD receiving a gluten-free diet. RESULTS: The neurophysiological tests revealed subclinical neurological abnormalities associated with CD in 3 (11%) of 27 children: 2 had peripheral polyneuropathy documented with electromyography, and 1 had prolonged latencies in somatosensory evoked potential. Magnetic resonance imaging showed abnormalities in 2 (7.4%) of children: pontine demyelinization in 1 and cortical atrophy in the other. CONCLUSIONS: Because the rate of neurological problems is increased in children with CD, neurological abnormalities should be carefully investigated early after the diagnosis of CD is made.
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